Assay Detail
Binding
CHEMBL3412867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat lenses ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured after 5 mins by spectrophotometry
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.41 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3409347 | — | — | 1 | 7.50 |
| CHEMBL3409362 | — | — | 1 | 7.25 |
| CHEMBL3409344 | — | — | 1 | 7.20 |
| CHEMBL3409348 | — | — | 1 | 7.16 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.08 |
| CHEMBL3409349 | — | — | 1 | 7.04 |
| CHEMBL3409345 | — | — | 1 | 7.02 |
| CHEMBL3409346 | — | — | 1 | 6.86 |
| CHEMBL3261531 | — | — | 1 | 6.84 |
| CHEMBL3409367 | — | — | 1 | 6.82 |
| CHEMBL3409363 | — | — | 1 | 6.80 |
| CHEMBL3409366 | — | — | 1 | 6.74 |
| CHEMBL3409357 | — | — | 1 | 6.72 |
| CHEMBL3409353 | — | — | 1 | 6.62 |
| CHEMBL3409361 | — | — | 1 | 6.56 |
| CHEMBL3409356 | — | — | 1 | 6.53 |
| CHEMBL3409360 | — | — | 1 | 6.50 |
| CHEMBL3409358 | — | — | 1 | 6.49 |
| CHEMBL3409352 | — | — | 1 | 6.43 |
| CHEMBL3409343 | — | — | 1 | 6.40 |
| CHEMBL3409364 | — | — | 1 | 6.40 |
| CHEMBL3409355 | — | — | 1 | 6.38 |
| CHEMBL3409369 | — | — | 1 | 6.38 |
| CHEMBL3409359 | — | — | 1 | 6.33 |
| CHEMBL3409354 | — | — | 1 | 6.33 |
| CHEMBL3409351 | — | — | 1 | 6.19 |
| CHEMBL3409371 | — | — | 1 | 6.19 |
| CHEMBL3409370 | — | — | 1 | 6.10 |
| CHEMBL3261527 | — | — | 1 | 6.09 |
| CHEMBL3409339 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3409347 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3409362 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3409344 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3409348 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3409349 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3409345 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3409346 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL3261531 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3409367 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3409363 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3409366 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3409357 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3409353 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL3409361 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3409356 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL3409360 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL3409358 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL3409352 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL3409343 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL3409364 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL3409355 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL3409369 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL3409359 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL3409354 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL3409351 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL3409371 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL3409370 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL3261527 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3409339 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL3409365 | — | IC50 | = | 1112.0 | nM | 5.95 |
| CHEMBL3409340 | — | IC50 | = | 1516.0 | nM | 5.82 |
| CHEMBL3409341 | — | IC50 | = | 2131.0 | nM | 5.67 |
| CHEMBL3409342 | — | IC50 | = | 2592.0 | nM | 5.59 |
| CHEMBL3409350 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL3409338 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL3409368 | — | IC50 | = | 4181.0 | nM | 5.38 |
| CHEMBL1580909 | — | IC50 | = | 5981.0 | nM | 5.22 |