Assay Detail
Binding
CHEMBL3412926
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Binding affinity to recombinant human neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured for 5 mins by oxyhemoglobin NO capture assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.64 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480419 | — | — | 1 | 7.16 |
| CHEMBL3407814 | — | — | 1 | 6.90 |
| CHEMBL3407811 | — | — | 1 | 6.90 |
| CHEMBL3407815 | — | — | 1 | 6.86 |
| CHEMBL3407822 | — | — | 1 | 6.86 |
| CHEMBL3407810 | — | — | 1 | 6.71 |
| CHEMBL3407821 | — | — | 1 | 6.52 |
| CHEMBL3407812 | — | — | 1 | 6.45 |
| CHEMBL3407813 | — | — | 1 | 6.45 |
| CHEMBL3407809 | — | — | 1 | 6.12 |
| CHEMBL3407823 | — | — | 1 | 6.06 |
| CHEMBL3407808 | — | — | 1 | - |
| CHEMBL3407805 | — | — | 1 | - |
| CHEMBL3407816 | — | — | 1 | - |
| CHEMBL3407817 | — | — | 1 | - |
| CHEMBL3407818 | — | — | 1 | - |
| CHEMBL3407819 | — | — | 1 | - |
| CHEMBL3407820 | — | — | 1 | - |
| CHEMBL3407807 | — | — | 1 | - |
| CHEMBL3407806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480419 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3407814 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL3407811 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL3407815 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL3407822 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL3407810 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL3407821 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL3407812 | — | Ki | = | 359.0 | nM | 6.45 |
| CHEMBL3407813 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL3407809 | — | Ki | = | 758.0 | nM | 6.12 |
| CHEMBL3407823 | — | Ki | = | 873.0 | nM | 6.06 |
| CHEMBL3407808 | — | Ki | - | — | - | |
| CHEMBL3407805 | — | Ki | - | — | - | |
| CHEMBL3407816 | — | Ki | - | — | - | |
| CHEMBL3407817 | — | Ki | - | — | - | |
| CHEMBL3407818 | — | Ki | - | — | - | |
| CHEMBL3407819 | — | Ki | - | — | - | |
| CHEMBL3407820 | — | Ki | - | — | - | |
| CHEMBL3407807 | — | Ki | - | — | - | |
| CHEMBL3407806 | — | Ki | - | — | - |