Assay Detail
Binding
CHEMBL3412979
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Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.66 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410954 | — | — | 1 | 7.63 |
| CHEMBL3410955 | — | — | 1 | 6.84 |
| CHEMBL3410953 | — | — | 1 | 6.67 |
| CHEMBL3410956 | — | — | 1 | 6.64 |
| CHEMBL3410951 | — | — | 1 | 6.55 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.36 |
| CHEMBL3410957 | — | — | 1 | 6.34 |
| CHEMBL3410952 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410954 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL3410955 | — | IC50 | = | 143.7 | nM | 6.84 |
| CHEMBL3410953 | — | IC50 | = | 215.3 | nM | 6.67 |
| CHEMBL3410956 | — | IC50 | = | 226.5 | nM | 6.64 |
| CHEMBL3410951 | — | IC50 | = | 283.8 | nM | 6.55 |
| CHEMBL95 | TACRINE | IC50 | = | 435.1 | nM | 6.36 |
| CHEMBL3410957 | — | IC50 | = | 453.3 | nM | 6.34 |
| CHEMBL3410952 | — | IC50 | = | 535.0 | nM | 6.27 |