Assay Detail
Binding
CHEMBL3412980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.62 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410952 | — | — | 1 | 8.28 |
| CHEMBL3410953 | — | — | 1 | 7.99 |
| CHEMBL3410955 | — | — | 1 | 7.72 |
| CHEMBL3410954 | — | — | 1 | 7.69 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.63 |
| CHEMBL3410956 | — | — | 1 | 7.46 |
| CHEMBL3410951 | — | — | 1 | 7.25 |
| CHEMBL3410957 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410952 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3410953 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL3410955 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL3410954 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL95 | TACRINE | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL3410956 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL3410951 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL3410957 | — | IC50 | = | 110.1 | nM | 6.96 |