Assay Detail
Binding
CHEMBL3413040
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Inhibition of hedgehog signaling in mouse C3H10T1/2 cells assessed as reduction in Gli1 mRNA level after 24 hrs by quantitative PCR analysis
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C3H 10T1/2 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 15 | - | - |
| IC50 | 15 | 5.90 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408016 | — | — | 2 | 6.50 |
| CHEMBL3408015 | — | — | 2 | 6.40 |
| CHEMBL2407295 | — | — | 2 | 6.13 |
| CHEMBL3407996 | — | — | 2 | 6.10 |
| CHEMBL3408158 | — | — | 2 | 6.01 |
| CHEMBL3408162 | — | — | 2 | 6.00 |
| CHEMBL3408014 | — | — | 2 | 6.00 |
| CHEMBL3408163 | — | — | 2 | 5.92 |
| CHEMBL3408013 | — | — | 2 | 5.92 |
| CHEMBL3408161 | — | — | 2 | 5.82 |
| CHEMBL3408012 | — | — | 2 | 5.75 |
| CHEMBL3408165 | — | — | 2 | 5.62 |
| CHEMBL3407998 | — | — | 2 | 5.58 |
| CHEMBL3408007 | — | — | 2 | 5.41 |
| CHEMBL1042 | CHOLECALCIFEROL | 4.0 | 2 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408016 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3408015 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2407295 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3407996 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3408158 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3408162 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3408014 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3408163 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3408013 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3408161 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3408012 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3408165 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3407998 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3408007 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1042 | CHOLECALCIFEROL | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3408163 | — | Inhibition | - | % | - | |
| CHEMBL3408162 | — | Inhibition | - | % | - | |
| CHEMBL3408161 | — | Inhibition | - | % | - | |
| CHEMBL3408158 | — | Inhibition | - | % | - | |
| CHEMBL3408016 | — | Inhibition | - | % | - | |
| CHEMBL3408015 | — | Inhibition | - | % | - | |
| CHEMBL3408014 | — | Inhibition | - | % | - | |
| CHEMBL3408013 | — | Inhibition | - | % | - | |
| CHEMBL3408012 | — | Inhibition | - | % | - | |
| CHEMBL3408007 | — | Inhibition | - | % | - | |
| CHEMBL3407998 | — | Inhibition | - | % | - | |
| CHEMBL3407996 | — | Inhibition | - | % | - | |
| CHEMBL2407295 | — | Inhibition | - | % | - | |
| CHEMBL1042 | CHOLECALCIFEROL | Inhibition | - | % | - | |
| CHEMBL3408165 | — | Inhibition | - | % | - |