Assay Detail
Binding
CHEMBL3413189
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Inhibition of WNT signaling in human T-Rex HEK293 Tet-O cells harboring dominant negative form of Axin GSK3beta-interacting domain after 4 days by luciferase reporter assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.72 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408184 | — | — | 1 | 7.62 |
| CHEMBL1673059 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408184 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1673059 | — | IC50 | = | 1500.0 | nM | 5.82 |