Assay Detail
Functional
CHEMBL3413259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei rhodesiense STIB 900 assessed as parasite growth inhibition after 72 hrs by Alamar Blue assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.15 |
| CHEMBL3410620 | — | — | 1 | 6.47 |
| CHEMBL3410622 | — | — | 1 | 6.04 |
| CHEMBL3410634 | — | — | 1 | 5.96 |
| CHEMBL3410628 | — | — | 1 | 5.76 |
| CHEMBL3410631 | — | — | 1 | 5.74 |
| CHEMBL3410636 | — | — | 1 | 5.54 |
| CHEMBL3407532 | — | — | 1 | 5.39 |
| CHEMBL3410625 | — | — | 1 | 5.15 |
| CHEMBL3410624 | — | — | 1 | 5.00 |
| CHEMBL3410638 | — | — | 1 | 4.94 |
| CHEMBL3410623 | — | — | 1 | 4.79 |
| CHEMBL3410626 | — | — | 1 | 4.77 |
| CHEMBL3410635 | — | — | 1 | 4.58 |
| CHEMBL3410627 | — | — | 1 | 4.47 |
| CHEMBL3410629 | — | — | 1 | 4.29 |
| CHEMBL3410633 | — | — | 1 | 4.18 |
| CHEMBL3410621 | — | — | 1 | 4.13 |
| CHEMBL3410639 | — | — | 1 | 4.12 |
| CHEMBL3410630 | — | — | 1 | 4.12 |
| CHEMBL3410632 | — | — | 1 | - |
| CHEMBL3410637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3410620 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL3410622 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL3410634 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3410628 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3410631 | — | IC50 | = | 1838.0 | nM | 5.74 |
| CHEMBL3410636 | — | IC50 | = | 2877.0 | nM | 5.54 |
| CHEMBL3407532 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL3410625 | — | IC50 | = | 7035.0 | nM | 5.15 |
| CHEMBL3410624 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3410638 | — | IC50 | = | 11596.0 | nM | 4.94 |
| CHEMBL3410623 | — | IC50 | = | 16066.0 | nM | 4.79 |
| CHEMBL3410626 | — | IC50 | = | 17015.0 | nM | 4.77 |
| CHEMBL3410635 | — | IC50 | = | 26610.0 | nM | 4.58 |
| CHEMBL3410627 | — | IC50 | = | 34067.0 | nM | 4.47 |
| CHEMBL3410629 | — | IC50 | = | 51710.0 | nM | 4.29 |
| CHEMBL3410633 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL3410621 | — | IC50 | = | 73870.0 | nM | 4.13 |
| CHEMBL3410639 | — | IC50 | = | 76250.0 | nM | 4.12 |
| CHEMBL3410630 | — | IC50 | = | 76550.0 | nM | 4.12 |
| CHEMBL3410632 | — | IC50 | = | 153160.0 | nM | - |
| CHEMBL3410637 | — | IC50 | = | 220860.0 | nM | - |