Assay Detail
Binding
CHEMBL3413272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant full-length Trypanosoma cruzi CYP51 by UV-spectrophotometric analysis
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sterol 14-alpha demethylase (CHEMBL1075110) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi (strain CL Brener) |
Publication
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.17 | 7.64 |
| Kd(app) | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410636 | — | — | 1 | 7.64 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 6.64 |
| CHEMBL3410635 | — | — | 1 | 6.22 |
| CHEMBL2070694 | — | — | 1 | 4.19 |
| CHEMBL3410620 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410636 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL106 | FLUCONAZOLE | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL3410635 | — | Kd | = | 606.0 | nM | 6.22 |
| CHEMBL2070694 | — | Kd | = | 65200.0 | nM | 4.19 |
| CHEMBL3410620 | — | Kd(app) | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | Kd(app) | - | — | - |