Assay Detail
Binding
CHEMBL3413435
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Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.55 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.80 |
| CHEMBL3407591 | — | — | 1 | 6.28 |
| CHEMBL3407581 | — | — | 1 | 5.55 |
| CHEMBL1929421 | — | — | 1 | 5.47 |
| CHEMBL3407585 | — | — | 1 | 5.34 |
| CHEMBL3407584 | — | — | 1 | 5.31 |
| CHEMBL3407582 | — | — | 1 | 5.08 |
| CHEMBL3407586 | — | — | 1 | 5.02 |
| CHEMBL3407587 | — | — | 1 | 4.87 |
| CHEMBL3407583 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3407591 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3407581 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1929421 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3407585 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3407584 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3407582 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3407586 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3407587 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3407583 | — | IC50 | = | 15400.0 | nM | 4.81 |