Assay Detail
Binding
CHEMBL3413522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PI3Kalpha (unknown origin) using biotinylated PIP2 as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.50 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030451 | — | — | 1 | 6.25 |
| CHEMBL3410675 | — | — | 1 | 6.25 |
| CHEMBL3410672 | — | — | 1 | 6.04 |
| CHEMBL3410548 | — | — | 1 | 5.49 |
| CHEMBL3410642 | — | — | 1 | 5.10 |
| CHEMBL1312643 | — | — | 1 | 4.76 |
| CHEMBL2030436 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030451 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL3410675 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL3410672 | — | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL3410548 | — | IC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL3410642 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1312643 | — | IC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL2030436 | — | IC50 | = | 26302.68 | nM | 4.58 |