Assay Detail
Functional
CHEMBL3413623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.44 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3407783 | — | — | 1 | 9.60 |
| CHEMBL3407774 | — | — | 1 | 9.49 |
| CHEMBL3407784 | — | — | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3407783 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3407774 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3407784 | — | EC50 | = | 0.6 | nM | 9.22 |