Assay Detail
Functional
CHEMBL3413740
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Negative ionotropic activity in guinea pig left atrium assessed as decrease in developed tension driven at 1 Hz
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.59 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408529 | — | — | 1 | 8.22 |
| CHEMBL3408528 | — | — | 1 | 8.03 |
| CHEMBL3408531 | — | — | 1 | 8.01 |
| CHEMBL3408530 | — | — | 1 | 7.96 |
| CHEMBL3408526 | — | — | 1 | 7.89 |
| CHEMBL3408523 | — | — | 1 | 7.66 |
| CHEMBL3408524 | — | — | 1 | 7.58 |
| CHEMBL3408525 | — | — | 1 | 7.47 |
| CHEMBL211204 | — | — | 1 | 7.40 |
| CHEMBL441691 | — | — | 1 | 7.16 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408529 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3408528 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3408531 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3408530 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3408526 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3408523 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3408524 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3408525 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL211204 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL441691 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL23 | DILTIAZEM | EC50 | = | 790.0 | nM | 6.10 |