Assay Detail
Binding
CHEMBL3413889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Cav1.2a in K+-depolarized guinea pig aortic strips assessed as inhibition of calcium-induced contraction
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.74 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408526 | — | — | 1 | 7.89 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408526 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 2600.0 | nM | 5.58 |