Assay Detail
Functional
CHEMBL3413997
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Antiviral activity against X4 tropic HIV-1 clone pNL4-3 infected in H9 cells assessed as reduction in p24 antigen after 4 days by ELISA
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.98 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410117 | — | — | 1 | 8.46 |
| CHEMBL1586201 | — | — | 1 | 7.24 |
| CHEMBL374632 | — | — | 1 | 6.62 |
| CHEMBL3410129 | — | — | 1 | 6.54 |
| CHEMBL3407527 | — | — | 1 | 6.44 |
| CHEMBL116701 | — | — | 1 | 6.29 |
| CHEMBL3410126 | — | — | 1 | 6.14 |
| CHEMBL3410147 | — | — | 1 | 6.12 |
| CHEMBL3410144 | — | — | 1 | 5.98 |
| CHEMBL3410118 | — | — | 1 | 5.96 |
| CHEMBL3410139 | — | — | 1 | 5.95 |
| CHEMBL3410138 | — | — | 1 | 5.90 |
| CHEMBL3410140 | — | — | 1 | 5.87 |
| CHEMBL1164812 | — | — | 1 | 5.82 |
| CHEMBL3410143 | — | — | 1 | 5.79 |
| CHEMBL3410141 | — | — | 1 | 5.78 |
| CHEMBL3410133 | — | — | 1 | 5.62 |
| CHEMBL3410146 | — | — | 1 | 5.57 |
| CHEMBL116847 | — | — | 1 | 5.54 |
| CHEMBL3410119 | — | — | 1 | 5.48 |
| CHEMBL3410149 | — | — | 1 | 5.45 |
| CHEMBL3410145 | — | — | 1 | 5.36 |
| CHEMBL3410134 | — | — | 1 | 5.23 |
| CHEMBL3410123 | — | — | 1 | 5.21 |
| CHEMBL3410148 | — | — | 1 | 5.14 |
| CHEMBL3410116 | — | — | 1 | - |
| CHEMBL3410121 | — | — | 1 | - |
| CHEMBL3410120 | — | — | 1 | - |
| CHEMBL1163357 | — | — | 1 | - |
| CHEMBL1165307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410117 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL1586201 | — | IC50 | = | 58.03 | nM | 7.24 |
| CHEMBL374632 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3410129 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3407527 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL116701 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3410126 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3410147 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3410144 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3410118 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3410139 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3410138 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3410140 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1164812 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3410143 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL3410141 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3410133 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3410146 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL116847 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL3410119 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3410149 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL3410145 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL3410134 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL3410123 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL3410148 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3410125 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410136 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410135 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410132 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410131 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410130 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410128 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410150 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410127 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1933875 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1933870 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410142 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410116 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410124 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410122 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410137 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410113 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410114 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1933873 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410115 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1165307 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1163357 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410120 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3410121 | — | IC50 | > | 50000.0 | nM | - |