Assay Detail
Binding
CHEMBL3418290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stimulation for 10 mins by quantitative electrochemiluminescence immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.98 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414918 | — | — | 1 | 8.52 |
| CHEMBL3414922 | — | — | 1 | 8.40 |
| CHEMBL3414917 | — | — | 1 | 8.40 |
| CHEMBL3414926 | — | — | 1 | 8.30 |
| CHEMBL3414925 | — | — | 1 | 8.22 |
| CHEMBL3414577 | — | — | 1 | 8.22 |
| CHEMBL3414738 | — | — | 1 | 8.15 |
| CHEMBL3414914 | — | — | 1 | 8.15 |
| CHEMBL3414919 | — | — | 1 | 8.15 |
| CHEMBL3414913 | — | — | 1 | 8.10 |
| CHEMBL3414736 | — | — | 1 | 8.05 |
| CHEMBL3414920 | — | — | 1 | 7.92 |
| CHEMBL3414915 | — | — | 1 | 7.89 |
| CHEMBL3414923 | — | — | 1 | 7.82 |
| CHEMBL3414739 | — | — | 1 | 7.82 |
| CHEMBL3414921 | — | — | 1 | 7.66 |
| CHEMBL3414740 | — | — | 1 | 7.60 |
| CHEMBL3414735 | — | — | 1 | 7.50 |
| CHEMBL3414737 | — | — | 1 | 7.46 |
| CHEMBL3414929 | — | — | 1 | 7.17 |
| CHEMBL3414916 | — | — | 1 | - |
| CHEMBL3414924 | — | — | 1 | - |
| CHEMBL3414927 | — | — | 1 | - |
| CHEMBL3414928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414918 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3414922 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3414917 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3414926 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3414925 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3414577 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3414738 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3414914 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3414919 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3414913 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3414736 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3414920 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3414915 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3414923 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3414739 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3414921 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3414740 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3414735 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3414737 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3414929 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3414916 | — | IC50 | - | — | - | |
| CHEMBL3414924 | — | IC50 | - | — | - | |
| CHEMBL3414927 | — | IC50 | - | — | - | |
| CHEMBL3414928 | — | IC50 | - | — | - |