Assay Detail
Functional
CHEMBL3418331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.27 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236715 | — | — | 1 | 9.05 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.22 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL3330984 | — | — | 1 | 7.30 |
| CHEMBL3415138 | — | — | 1 | 6.58 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.51 |
| CHEMBL3415142 | — | — | 1 | 6.50 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 6.27 |
| CHEMBL3415150 | — | — | 1 | 6.06 |
| CHEMBL3415148 | — | — | 1 | 6.01 |
| CHEMBL3415139 | — | — | 1 | 5.89 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.66 |
| CHEMBL3415143 | — | — | 1 | 5.64 |
| CHEMBL3415149 | — | — | 1 | 5.40 |
| CHEMBL3415151 | — | — | 1 | 5.34 |
| CHEMBL3415134 | — | — | 1 | 5.19 |
| CHEMBL3415146 | — | — | 1 | 5.14 |
| CHEMBL3415140 | — | — | 1 | 5.04 |
| CHEMBL3415144 | — | — | 1 | 4.72 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 4.64 |
| CHEMBL3415147 | — | — | 1 | - |
| CHEMBL3415145 | — | — | 1 | - |
| CHEMBL3415141 | — | — | 1 | - |
| CHEMBL3415137 | — | — | 1 | - |
| CHEMBL3415136 | — | — | 1 | - |
| CHEMBL3415135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236715 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3330984 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3415138 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3415142 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3415150 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3415148 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3415139 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3415143 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3415149 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3415151 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3415134 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3415146 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3415140 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3415144 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3415147 | — | EC50 | > | 28000.0 | nM | - |
| CHEMBL3415145 | — | EC50 | > | 13000.0 | nM | - |
| CHEMBL3415141 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL3415137 | — | EC50 | > | 57000.0 | nM | - |
| CHEMBL3415136 | — | EC50 | > | 156000.0 | nM | - |
| CHEMBL3415135 | — | EC50 | > | 5300.0 | nM | - |