Assay Detail
Binding
CHEMBL3418490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrate
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.46 | 8.15 |
| Ki | 13 | 8.15 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392006 | — | — | 2 | 8.92 |
| CHEMBL3415119 | — | — | 2 | 8.85 |
| CHEMBL3415124 | — | — | 2 | 8.72 |
| CHEMBL3415125 | — | — | 2 | 8.10 |
| CHEMBL3415117 | — | — | 2 | 7.64 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 7.42 |
| CHEMBL3415123 | — | — | 2 | 7.39 |
| CHEMBL3415127 | — | — | 2 | 7.21 |
| CHEMBL3415126 | — | — | 2 | 6.66 |
| CHEMBL3415118 | — | — | 2 | - |
| CHEMBL3415120 | — | — | 2 | - |
| CHEMBL3415121 | — | — | 2 | - |
| CHEMBL3415122 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392006 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3415119 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3415124 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3415124 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2392006 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3415125 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3415119 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3415125 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3415117 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3415123 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3415123 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3415127 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3415117 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3415126 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3415121 | — | IC50 | - | — | - | |
| CHEMBL3415120 | — | Ki | - | — | - | |
| CHEMBL3415121 | — | Ki | - | — | - | |
| CHEMBL3415122 | — | Ki | - | — | - | |
| CHEMBL3415118 | — | Ki | - | — | - | |
| CHEMBL3415120 | — | IC50 | - | — | - | |
| CHEMBL3415118 | — | IC50 | - | — | - | |
| CHEMBL3415126 | — | Ki | - | — | - | |
| CHEMBL3415127 | — | Ki | - | — | - | |
| CHEMBL3415122 | — | IC50 | - | — | - |