Assay Detail

CHEMBL3418494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Growth inhibition of human castration-resistant prostate cancer cells

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Cancer cell lines
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.

Njar VC, Brodie AM.
J Med Chem (2015) 58 : 2077 -2087
PubMed 25591066 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.15	5.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2105738	GALETERONE	3.0	1	5.54
CHEMBL409	BICALUTAMIDE	4.0	1	4.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2105738	GALETERONE	IC50	=	2900.0	nM	5.54
CHEMBL409	BICALUTAMIDE	IC50	=	18000.0	nM	4.75