Assay Detail
Binding
CHEMBL3418529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain MAO-B in nuclei-free homogenates using [14C]phenylacetaldehyde substrate after 20 mins by liquid scintillation counting
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.68 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415801 | — | — | 1 | 6.70 |
| CHEMBL3415613 | — | — | 1 | 6.40 |
| CHEMBL3415798 | — | — | 1 | 6.18 |
| CHEMBL3415788 | — | — | 1 | 6.18 |
| CHEMBL3415787 | — | — | 1 | 6.16 |
| CHEMBL3415612 | — | — | 1 | 6.16 |
| CHEMBL3415785 | — | — | 1 | 6.16 |
| CHEMBL3415820 | — | — | 1 | 6.16 |
| CHEMBL3415804 | — | — | 1 | 6.10 |
| CHEMBL3415815 | — | — | 1 | 6.00 |
| CHEMBL3415817 | — | — | 1 | 6.00 |
| CHEMBL3415819 | — | — | 1 | 6.00 |
| CHEMBL3415789 | — | — | 1 | 6.00 |
| CHEMBL3415792 | — | — | 1 | 6.00 |
| CHEMBL3415800 | — | — | 1 | 5.82 |
| CHEMBL3415614 | — | — | 1 | 5.82 |
| CHEMBL3415810 | — | — | 1 | 5.70 |
| CHEMBL3415793 | — | — | 1 | 5.70 |
| CHEMBL3415797 | — | — | 1 | 5.70 |
| CHEMBL3415805 | — | — | 1 | 5.60 |
| CHEMBL3415795 | — | — | 1 | 5.60 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 5.52 |
| CHEMBL3415814 | — | — | 1 | 5.48 |
| CHEMBL3415818 | — | — | 1 | 5.40 |
| CHEMBL3415796 | — | — | 1 | 5.30 |
| CHEMBL3415799 | — | — | 1 | 5.30 |
| CHEMBL3415802 | — | — | 1 | 5.30 |
| CHEMBL3415816 | — | — | 1 | 5.30 |
| CHEMBL3415616 | — | — | 1 | 5.30 |
| CHEMBL3415617 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415801 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3415613 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3415788 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3415798 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3415787 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415612 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415785 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415820 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415804 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3415789 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415792 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415819 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415817 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415815 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415614 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3415800 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3415810 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3415793 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3415797 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3415805 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3415795 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL887 | RASAGILINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3415814 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3415818 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3415796 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415799 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415802 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415816 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415616 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415617 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3415807 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3415791 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL3415808 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3415794 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415790 | — | IC50 | - | — | - | |
| CHEMBL3415811 | — | IC50 | - | — | - | |
| CHEMBL3415812 | — | IC50 | - | — | - | |
| CHEMBL3415813 | — | IC50 | - | — | - | |
| CHEMBL3415615 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415780 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415806 | — | IC50 | - | — | - | |
| CHEMBL3414586 | — | IC50 | - | — | - | |
| CHEMBL3415809 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3415803 | — | IC50 | - | — | - |