Assay Detail
Functional
CHEMBL3418579
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Anticancer activity against human SMMC7721 cells assessed as cell survival after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of celastrol derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.49 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417316 | — | — | 1 | 6.52 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.24 |
| CHEMBL3417317 | — | — | 1 | 6.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.91 |
| CHEMBL3417321 | — | — | 1 | 5.74 |
| CHEMBL3417322 | — | — | 1 | 5.59 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.31 |
| CHEMBL3417318 | — | — | 1 | 5.16 |
| CHEMBL3417314 | — | — | 1 | 5.12 |
| CHEMBL3417313 | — | — | 1 | 5.03 |
| CHEMBL3417319 | — | — | 1 | 4.97 |
| CHEMBL3417320 | — | — | 1 | 4.91 |
| CHEMBL3417315 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417316 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL301982 | CELASTROL | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3417317 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3417321 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3417322 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL3417318 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL3417314 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL3417313 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL3417319 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3417320 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL3417315 | — | IC50 | = | 19970.0 | nM | 4.70 |