Assay Detail
Functional
CHEMBL3418917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human HeLa-CD4-LTR-beta-gal cells after 1 day by spectroscopic analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 5.58 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.80 |
| CHEMBL3415832 | — | — | 1 | 6.25 |
| CHEMBL3415845 | — | — | 1 | 6.24 |
| CHEMBL3415846 | — | — | 1 | 6.20 |
| CHEMBL3415843 | — | — | 1 | 6.18 |
| CHEMBL3415853 | — | — | 1 | 6.16 |
| CHEMBL3415842 | — | — | 1 | 6.16 |
| CHEMBL3415833 | — | — | 1 | 6.05 |
| CHEMBL499273 | — | — | 1 | 6.00 |
| CHEMBL3415841 | — | — | 1 | 5.92 |
| CHEMBL3415856 | — | — | 1 | 5.70 |
| CHEMBL3238122 | — | — | 1 | 5.44 |
| CHEMBL3415840 | — | — | 1 | 5.37 |
| CHEMBL3415852 | — | — | 1 | 4.76 |
| CHEMBL3415835 | — | — | 1 | 4.72 |
| CHEMBL3415834 | — | — | 1 | 4.72 |
| CHEMBL3415836 | — | — | 1 | 4.70 |
| CHEMBL3415854 | — | — | 1 | 4.69 |
| CHEMBL3415837 | — | — | 1 | 4.32 |
| CHEMBL3415839 | — | — | 1 | 4.30 |
| CHEMBL3415847 | — | — | 1 | - |
| CHEMBL3415848 | — | — | 1 | - |
| CHEMBL3415851 | — | — | 1 | - |
| CHEMBL557770 | — | — | 1 | - |
| CHEMBL3415855 | — | — | 1 | - |
| CHEMBL3415844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3415832 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3415845 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3415846 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3415843 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3415853 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415842 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3415833 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL499273 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3415841 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3415856 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3238122 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3415840 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3415852 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3415835 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3415834 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3415836 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3415854 | — | EC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL3415837 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3415839 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3415847 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3415848 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3415851 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL557770 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3415855 | — | EC50 | < | 200.0 | nM | - |
| CHEMBL3415844 | — | EC50 | > | 50000.0 | nM | - |