Assay Detail
Binding
CHEMBL3418929
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In vitro inhibition of NADPH-reduced TrxR (unknown origin) after 2 hrs incubation by microplate reader
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 1 | 4.89 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32856 | — | — | 1 | 4.89 |
| CHEMBL32207 | — | — | 1 | - |
| CHEMBL1802076 | — | — | 1 | - |
| CHEMBL3416013 | — | — | 1 | - |
| CHEMBL3415863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32856 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL32207 | — | Inhibition | - | % | - | |
| CHEMBL1802076 | — | Inhibition | - | % | - | |
| CHEMBL3416013 | — | Inhibition | - | % | - | |
| CHEMBL3415863 | — | Inhibition | - | % | - |