Assay Detail
Binding
CHEMBL3418935
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Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.46 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32856 | — | — | 1 | 5.46 |
| CHEMBL253896 | XANTHOHUMOL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32856 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL253896 | XANTHOHUMOL | IC50 | > | 40000.0 | nM | - |