Assay Detail
Binding
CHEMBL3418947
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Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and profiling of a selective and efficacious Syk inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.87 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416027 | — | — | 1 | 9.00 |
| CHEMBL3416023 | — | — | 1 | 9.00 |
| CHEMBL3262356 | — | — | 1 | 8.40 |
| CHEMBL3416025 | — | — | 1 | 8.30 |
| CHEMBL3416024 | — | — | 1 | 8.30 |
| CHEMBL3262355 | — | — | 1 | 8.30 |
| CHEMBL2177736 | — | — | 1 | 7.89 |
| CHEMBL3416021 | — | — | 1 | 7.72 |
| CHEMBL3262624 | — | — | 1 | 7.66 |
| CHEMBL3416026 | — | — | 1 | 7.46 |
| CHEMBL3416028 | — | — | 1 | 7.03 |
| CHEMBL3416022 | — | — | 1 | 6.78 |
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416027 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3416023 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3262356 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3416025 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3416024 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3262355 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2177736 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3416021 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3262624 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3416026 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3416028 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3416022 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3265032 | ENTOSPLETINIB | IC50 | = | 377.0 | nM | 6.42 |