Assay Detail
ADMET
CHEMBL3418948
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Cytotoxicity against C57BL/6 mouse bone marrow cells assessed as growth inhibition preincubated for 4 days followed by [3H]-thymidine addition measured after 5 hrs by betaplate counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | Bone marrow cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and profiling of a selective and efficacious Syk inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.63 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262355 | — | — | 1 | 6.60 |
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 6.24 |
| CHEMBL3416025 | — | — | 1 | 6.09 |
| CHEMBL3416023 | — | — | 1 | 5.68 |
| CHEMBL3416021 | — | — | 1 | 5.58 |
| CHEMBL3262356 | — | — | 1 | 5.47 |
| CHEMBL3262624 | — | — | 1 | 5.45 |
| CHEMBL3416027 | — | — | 1 | 5.28 |
| CHEMBL3416024 | — | — | 1 | 5.28 |
| CHEMBL2177736 | — | — | 1 | 5.23 |
| CHEMBL3416026 | — | — | 1 | 5.04 |
| CHEMBL3416028 | — | — | 1 | - |
| CHEMBL3416022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262355 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3265032 | ENTOSPLETINIB | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL3416025 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL3416023 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3416021 | — | IC50 | = | 2601.0 | nM | 5.58 |
| CHEMBL3262356 | — | IC50 | = | 3411.0 | nM | 5.47 |
| CHEMBL3262624 | — | IC50 | = | 3515.0 | nM | 5.45 |
| CHEMBL3416027 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL3416024 | — | IC50 | = | 5267.0 | nM | 5.28 |
| CHEMBL2177736 | — | IC50 | = | 5853.0 | nM | 5.23 |
| CHEMBL3416026 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL3416028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3416022 | — | IC50 | > | 10000.0 | nM | - |