Assay Detail
Binding
CHEMBL3418949
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Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation measured after 15 mins by flow cytometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos B |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and profiling of a selective and efficacious Syk inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.86 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416027 | — | — | 1 | 7.85 |
| CHEMBL3416024 | — | — | 1 | 7.52 |
| CHEMBL3262624 | — | — | 1 | 7.26 |
| CHEMBL3416023 | — | — | 1 | 7.16 |
| CHEMBL3262356 | — | — | 1 | 7.05 |
| CHEMBL3416026 | — | — | 1 | 7.00 |
| CHEMBL3416025 | — | — | 1 | 6.98 |
| CHEMBL3416028 | — | — | 1 | 6.77 |
| CHEMBL2177736 | — | — | 1 | 6.75 |
| CHEMBL3416022 | — | — | 1 | 6.36 |
| CHEMBL3416021 | — | — | 1 | 6.35 |
| CHEMBL3262355 | — | — | 1 | 6.11 |
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416027 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3416024 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3262624 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3416023 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3262356 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3416026 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3416025 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3416028 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2177736 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3416022 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL3416021 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL3262355 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL3265032 | ENTOSPLETINIB | IC50 | = | 878.0 | nM | 6.06 |