Assay Detail
Binding
CHEMBL3418981
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Inhibition of Escherichia coli FtsZ GTPase activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.91 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293492 | CINNAMALDEHYDE | -1.0 | 1 | 5.24 |
| CHEMBL3416824 | — | — | 1 | 5.08 |
| CHEMBL1835968 | DICHAMANETIN | — | 1 | 4.90 |
| CHEMBL2418096 | — | — | 1 | 4.43 |
| CHEMBL1240857 | VIRIDITOXIN | — | 1 | - |
| CHEMBL2418095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293492 | CINNAMALDEHYDE | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL3416824 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1835968 | DICHAMANETIN | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2418096 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1240857 | VIRIDITOXIN | IC50 | = | 7.0 | ug.mL-1 | - |
| CHEMBL2418095 | — | IC50 | = | 6.7 | ug.mL-1 | - |