Assay Detail
Binding
CHEMBL3419481
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Binding affinity to human adenosine A2A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.42 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1950649 | APADENOSON | 3.0 | 1 | 9.30 |
| CHEMBL1096896 | UK432097 | 2.0 | 1 | 8.40 |
| CHEMBL1950554 | BINODENOSON | 3.0 | 1 | 6.57 |
| CHEMBL317052 | REGADENOSON ANHYDROUS | 4.0 | 1 | 6.54 |
| CHEMBL1950553 | SONEDENOSON | 2.0 | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1950649 | APADENOSON | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1096896 | UK432097 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1950554 | BINODENOSON | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL317052 | REGADENOSON ANHYDROUS | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL1950553 | SONEDENOSON | Ki | = | 490.0 | nM | 6.31 |