Assay Detail
Binding
CHEMBL3419489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.08 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 7.52 |
| CHEMBL3416806 | — | — | 1 | 7.44 |
| CHEMBL3416805 | — | — | 1 | 7.43 |
| CHEMBL3416808 | — | — | 1 | 7.41 |
| CHEMBL3416807 | — | — | 1 | 7.37 |
| CHEMBL3416810 | — | — | 1 | 7.21 |
| CHEMBL3416803 | — | — | 1 | 7.16 |
| CHEMBL3416809 | — | — | 1 | 6.61 |
| CHEMBL3416804 | — | — | 1 | 6.53 |
| CHEMBL331372 | CGS-21680 | — | 1 | 6.42 |
| CHEMBL3416811 | — | — | 1 | 6.36 |
| CHEMBL3414573 | — | — | 1 | 6.12 |
| CHEMBL3416784 | — | — | 1 | 6.12 |
| CHEMBL3416797 | — | — | 1 | 6.00 |
| CHEMBL3416790 | — | — | 1 | 5.93 |
| CHEMBL3416781 | — | — | 1 | 5.88 |
| CHEMBL3416793 | — | — | 1 | 5.86 |
| CHEMBL3416799 | — | — | 1 | 5.83 |
| CHEMBL3416796 | — | — | 1 | 5.81 |
| CHEMBL3416780 | — | — | 1 | 5.78 |
| CHEMBL3416798 | — | — | 1 | 5.74 |
| CHEMBL3416792 | — | — | 1 | 5.73 |
| CHEMBL3416779 | — | — | 1 | 5.73 |
| CHEMBL3416795 | — | — | 1 | 5.73 |
| CHEMBL3416783 | — | — | 1 | 5.69 |
| CHEMBL3416786 | — | — | 1 | 5.69 |
| CHEMBL3416775 | — | — | 1 | 5.67 |
| CHEMBL3416787 | — | — | 1 | 5.66 |
| CHEMBL3416785 | — | — | 1 | 5.58 |
| CHEMBL3416777 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3416806 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3416805 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3416808 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3416807 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3416810 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3416803 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3416809 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL3416804 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL331372 | CGS-21680 | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL3416811 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL3414573 | — | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL3416784 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL3416797 | — | Ki | = | 1003.0 | nM | 6.00 |
| CHEMBL3416790 | — | Ki | = | 1172.0 | nM | 5.93 |
| CHEMBL3416781 | — | Ki | = | 1306.0 | nM | 5.88 |
| CHEMBL3416793 | — | Ki | = | 1387.0 | nM | 5.86 |
| CHEMBL3416799 | — | Ki | = | 1487.0 | nM | 5.83 |
| CHEMBL3416796 | — | Ki | = | 1538.0 | nM | 5.81 |
| CHEMBL3416780 | — | Ki | = | 1677.0 | nM | 5.78 |
| CHEMBL3416798 | — | Ki | = | 1818.0 | nM | 5.74 |
| CHEMBL3416779 | — | Ki | = | 1874.0 | nM | 5.73 |
| CHEMBL3416795 | — | Ki | = | 1845.0 | nM | 5.73 |
| CHEMBL3416792 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL3416783 | — | Ki | = | 2034.0 | nM | 5.69 |
| CHEMBL3416786 | — | Ki | = | 2052.0 | nM | 5.69 |
| CHEMBL3416775 | — | Ki | = | 2161.0 | nM | 5.67 |
| CHEMBL3416787 | — | Ki | = | 2195.0 | nM | 5.66 |
| CHEMBL3416785 | — | Ki | = | 2655.0 | nM | 5.58 |
| CHEMBL3416777 | — | Ki | = | 3252.0 | nM | 5.49 |
| CHEMBL3416782 | — | Ki | = | 3382.0 | nM | 5.47 |
| CHEMBL3416800 | — | Ki | = | 3481.0 | nM | 5.46 |
| CHEMBL3416794 | — | Ki | = | 3425.0 | nM | 5.46 |
| CHEMBL3416778 | — | Ki | = | 4083.0 | nM | 5.39 |
| CHEMBL3416776 | — | Ki | = | 5502.0 | nM | 5.26 |
| CHEMBL3416789 | — | Ki | = | 5884.0 | nM | 5.23 |
| CHEMBL3416788 | — | Ki | = | 5833.0 | nM | 5.23 |
| CHEMBL3416802 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416801 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3416791 | — | Ki | > | 10000.0 | nM | - |