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Compound Detail

CHEMBL3416804

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CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCCOC)cc5)CC4)nc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL3416804
Phase Preclinical
Structure Type MOL
InChI Key DHSVSNGIGFVEQT-CMCWBKRRSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

542.6
MW (Da)
-0.48
ALogP
13
HBA
4
HBD
173.3
PSA (Ų)
0.26
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H34N8O6
MW 542.60
Aromatic Rings 3
Heavy Atoms 39
NP-Likeness -0.57

Activity Summary

Ki 3 meas. best 6.83

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL226
Ki 6.83 6.83 147.0 1
Adenosine receptor A3
CHEMBL256
Ki 6.53 6.53 293.0 1
Adenosine receptor A2a
CHEMBL251
Ki 6.17 6.17 682.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25780876 10.1021/acs.jmedchem.5b00215 Adenosine receptor A2a 3
25780876 10.1021/acs.jmedchem.5b00215 Adenosine receptor A2b 2
25780876 10.1021/acs.jmedchem.5b00215 Adenosine receptor A1 1
25780876 10.1021/acs.jmedchem.5b00215 Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine