Assay Detail
Binding
CHEMBL3419829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.88 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417199 | — | — | 1 | 6.62 |
| CHEMBL3417205 | — | — | 1 | 6.47 |
| CHEMBL3417198 | — | — | 1 | 6.46 |
| CHEMBL1240885 | — | — | 1 | 6.06 |
| CHEMBL3417207 | — | — | 1 | 6.05 |
| CHEMBL3417208 | — | — | 1 | 5.80 |
| CHEMBL3417204 | — | — | 1 | 5.58 |
| CHEMBL3417203 | — | — | 1 | 5.50 |
| CHEMBL3417202 | — | — | 1 | 5.22 |
| CHEMBL3417201 | — | — | 1 | 5.04 |
| CHEMBL3417206 | — | — | 1 | - |
| CHEMBL3417200 | — | — | 1 | - |
| CHEMBL3417197 | — | — | 1 | - |
| CHEMBL3417196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417199 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3417205 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3417198 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1240885 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL3417207 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3417208 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3417204 | — | Ki | = | 2630.0 | nM | 5.58 |
| CHEMBL3417203 | — | Ki | = | 3170.0 | nM | 5.50 |
| CHEMBL3417202 | — | Ki | = | 5990.0 | nM | 5.22 |
| CHEMBL3417201 | — | Ki | = | 9050.0 | nM | 5.04 |
| CHEMBL3417206 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3417200 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3417197 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3417196 | — | Ki | > | 10000.0 | nM | - |