Assay Detail
Functional
CHEMBL3420159
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Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of salinomycin conjugates with floxuridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.03 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.40 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 6.62 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 6.54 |
| CHEMBL3416849 | — | — | 1 | 6.43 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.65 |
| CHEMBL3416848 | — | — | 1 | 4.54 |
| CHEMBL1791034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3416849 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL3416848 | — | IC50 | = | 28650.0 | nM | 4.54 |
| CHEMBL1791034 | — | IC50 | = | 179740.0 | nM | - |