Assay Detail
Binding
CHEMBL3420249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/udorn/1972(H3N2)) M2 V27A mutant channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltage clamp assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.63 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3415948 | — | — | 1 | 4.76 |
| CHEMBL3305169 | — | — | 1 | 4.65 |
| CHEMBL3415949 | — | — | 1 | 4.49 |
| CHEMBL3415952 | — | — | 1 | - |
| CHEMBL3415951 | — | — | 1 | - |
| CHEMBL3415950 | — | — | 1 | - |
| CHEMBL3415947 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3415948 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3305169 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3415949 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL3415952 | — | IC50 | - | — | - | |
| CHEMBL3415951 | — | IC50 | - | — | - | |
| CHEMBL3415950 | — | IC50 | - | — | - | |
| CHEMBL3415947 | — | IC50 | = | 184600.0 | nM | - |