Matrix protein 2 · SINGLE PROTEIN · Influenza A virus (A/Udorn/307/1972(H3N2))
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As of 2026-09-13Matrix protein 2 shows approved-linked disease relevance led by infection. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P0DOF8. Start with infection, then reuse UniProt P0DOF8 as the stable protein anchor across project notes and exports.
Start with infection, then reuse UniProt P0DOF8 as the stable protein anchor across project notes and exports.
Matrix protein 2 shows approved-linked disease relevance led by infection. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with infection because it currently carries approved-linked support. Linked drugs include RIMANTADINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMatrix protein 2
Review this target as Matrix protein 2, mapped to UniProt P0DOF8. Sequence length is 97 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Matrix protein 2 as ChEMBL target CHEMBL2052, mapped to UniProt P0DOF8. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Matrix protein 2 is the right protein anchor across sources, using UniProt P0DOF8 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Matrix protein 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
| UniProt | P0DOF8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Matrix protein 2 |
| UniProt Accession | P0DOF8 |
| Component Type | Protein |
| Sequence Length | 97 aa |
Matrix protein 2
Review this target as Matrix protein 2, mapped to UniProt P0DOF8. Sequence length is 97 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Matrix protein 2 shows approved-linked disease relevance led by infection. 1 more disease program remain visible in the same review block.
Start review with infection because it currently carries approved-linked support. Linked drugs include RIMANTADINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4277990 | 8.1 | EC50 | 8.0 | Preclinical |
| CHEMBL4277543 | 6.89 | Kd | 130.0 | Preclinical |
| CHEMBL4284419 | 6.85 | EC50 | 140.0 | Preclinical |
| CHEMBL4277167 | 6.8 | EC50 | 160.0 | Preclinical |
| CHEMBL3088292 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL3770480 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL3088159 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL4291537 | 6.5 | EC50 | 320.0 | Preclinical |
| CHEMBL1235691 | 6.5 | Kd | 320.0 | Preclinical |
| CHEMBL3392935 | 6.47 | Kd | 340.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 61 | 48 | 5.1 |
| assay format | 20 | 43 | 5.4 |
| cell membrane format | 13 | 20 | 5.3 |
| single protein format | 2 | 7 | 6.1 |