Assay Detail
Functional
CHEMBL3420255
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Antiviral activity against Influenza A virus (A/HK/7/87(H3N2)) infected in MDCK cells assessed as virus plaque reduction preincubated for 1 hr followed by compound wash out and incubated for 72 hrs by crystal violet staining
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Hong Kong/7/1987(H3N2)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.48 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.70 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.85 |
| CHEMBL3415947 | — | — | 1 | 6.43 |
| CHEMBL3415948 | — | — | 1 | 6.27 |
| CHEMBL3415951 | — | — | 1 | 5.17 |
| CHEMBL3415949 | — | — | 1 | - |
| CHEMBL3415950 | — | — | 1 | - |
| CHEMBL3415952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL660 | AMANTADINE | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3415947 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3415948 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3415951 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3415949 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3415950 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3415952 | — | EC50 | > | 100000.0 | nM | - |