Assay Detail
Functional
CHEMBL3421200
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Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.86 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414608 | — | — | 1 | 6.12 |
| CHEMBL3414609 | — | — | 1 | 5.37 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.00 |
| CHEMBL3414612 | — | — | 1 | 4.77 |
| CHEMBL3414611 | — | — | 1 | 4.76 |
| CHEMBL3414613 | — | — | 1 | 4.71 |
| CHEMBL3414614 | — | — | 1 | 4.68 |
| CHEMBL3414610 | — | — | 1 | 4.22 |
| CHEMBL3414616 | — | — | 1 | 4.10 |
| CHEMBL3414606 | — | — | 1 | - |
| CHEMBL3414607 | — | — | 1 | - |
| CHEMBL3414615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414608 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3414609 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3414612 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3414611 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3414613 | — | EC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3414614 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3414610 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3414616 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3414606 | — | EC50 | > | 164000.0 | nM | - |
| CHEMBL3414607 | — | EC50 | > | 196000.0 | nM | - |
| CHEMBL3414615 | — | EC50 | = | 111000.0 | nM | - |