Assay Detail
Functional
CHEMBL3421202
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Antiviral activity against Sindbis virus HRsp infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sindbis virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.53 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.96 |
| CHEMBL3414614 | — | — | 1 | 4.54 |
| CHEMBL3414613 | — | — | 1 | 4.52 |
| CHEMBL3414608 | — | — | 1 | 4.36 |
| CHEMBL3414615 | — | — | 1 | 4.29 |
| CHEMBL3414606 | — | — | 1 | - |
| CHEMBL3414607 | — | — | 1 | - |
| CHEMBL3414609 | — | — | 1 | - |
| CHEMBL3414610 | — | — | 1 | - |
| CHEMBL3414611 | — | — | 1 | - |
| CHEMBL3414612 | — | — | 1 | - |
| CHEMBL3414616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3414614 | — | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL3414613 | — | EC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL3414608 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL3414615 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3414606 | — | EC50 | - | — | - | |
| CHEMBL3414607 | — | EC50 | > | 157000.0 | nM | - |
| CHEMBL3414609 | — | EC50 | > | 165000.0 | nM | - |
| CHEMBL3414610 | — | EC50 | > | 154000.0 | nM | - |
| CHEMBL3414611 | — | EC50 | > | 145000.0 | nM | - |
| CHEMBL3414612 | — | EC50 | > | 140000.0 | nM | - |
| CHEMBL3414616 | — | EC50 | > | 163000.0 | nM | - |