Assay Detail
Functional
CHEMBL3421426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 3b infected in human MT4 cells assessed as inhibition of virus replication after 5 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.01 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.00 |
| CHEMBL3414608 | — | — | 1 | 6.47 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.41 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 4.97 |
| CHEMBL3414611 | — | — | 1 | 4.67 |
| CHEMBL3414610 | — | — | 1 | 4.43 |
| CHEMBL3414606 | — | — | 1 | - |
| CHEMBL3414607 | — | — | 1 | - |
| CHEMBL3414609 | — | — | 1 | - |
| CHEMBL3414612 | — | — | 1 | - |
| CHEMBL3414613 | — | — | 1 | - |
| CHEMBL3414614 | — | — | 1 | - |
| CHEMBL3414615 | — | — | 1 | - |
| CHEMBL3414616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3414608 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3414611 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3414610 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL3414606 | — | IC50 | - | — | - | |
| CHEMBL3414607 | — | IC50 | > | 79000.0 | nM | - |
| CHEMBL3414609 | — | IC50 | > | 59000.0 | nM | - |
| CHEMBL3414612 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL3414613 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL3414614 | — | IC50 | > | 39000.0 | nM | - |
| CHEMBL3414615 | — | IC50 | > | 76000.0 | nM | - |
| CHEMBL3414616 | — | IC50 | > | 81000.0 | nM | - |