Assay Detail
Functional
CHEMBL3421430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against recombinant Human immunodeficiency virus 1 NL4.3 containing Renilla gene infected in CD3/IL2-activated human MT2 cells assessed as inhibition of virus replication pretreated for 2 hrs followed by viral infection for additional 2 hrs measured after 48 hrs by Renilla-luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414610 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414610 | — | IC50 | = | 2.0 | nM | 8.70 |