Assay Detail
Binding
CHEMBL3423533
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Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 30 mins followed by substrate addition by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.04 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570812 | — | — | 1 | 8.46 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.89 |
| CHEMBL3422944 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570812 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL184238 | URB-597 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3422944 | — | IC50 | = | 17.0 | nM | 7.77 |