Assay Detail
Binding
CHEMBL3424159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of histamine H1 receptor (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CNS drug design: balancing physicochemical properties for optimal brain exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.41 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 9.00 |
| CHEMBL914 | FEXOFENADINE | 4.0 | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL914 | FEXOFENADINE | IC50 | = | 15.0 | nM | 7.82 |