Compound Detail
CHEMBL914
FEXOFENADINE 💊 Approved Drug
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💊 Approved Drug
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Basic Information
| ChEMBL ID | CHEMBL914 |
| Name | FEXOFENADINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | RWTNPBWLLIMQHL-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
14
Activities
2
Assay Types
17
PK Parameters
20
Publications
3
Known Names
12
Indications
Molecular Properties
501.7
MW (Da)
5.51
ALogP
4
HBA
3
HBD
81.0
PSA (Ų)
0.34
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1996 |
| Availability | OTC |
| Chirality | Racemic |
Indications
Hypersensitivity Asthma Diabetic Nephropathies Pruritus Rhinitis, Allergic, Seasonal Dermatitis, Atopic Edema Gastroesophageal Reflux Rhinitis, Allergic, Perennial Arthritis, Rheumatoid Carcinoma, Non-Small-Cell Lung Prostatic Neoplasms
ATC Classification
R06AX26
fexofenadine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
Activity Summary
IC50 12 meas. best 7.82
Ki 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL231 | IC50 | 7.82 | 7.2875 | 15.0 | 4 |
| Histamine H1 receptor CHEMBL231 | Ki | 7.57 | 7.57 | 27.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 4.67 | 4.595 | 21379.6 | 8 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | Ki | 4.64 | 4.64 | 23000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 42.11 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 8.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.4 | mL.min-1.kg-1 | Homo sapiens |
| CL | 117.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 17.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| CL | 6.0 | mL.min-1.kg-1 | Macaca fascicularis |
| CL | 1.3 | mL.min-1.kg-1 | Homo sapiens |
| F | 30.0 | % | Homo sapiens |
| F | 30.0 | % | Homo sapiens |
| Fu | 0.78 | - | Homo sapiens |
| Fu | 0.00301 | - | Macaca fascicularis |
| Fu | 0.00421 | - | Homo sapiens |
| T1/2 | 18.3 | hr | Homo sapiens |
| Vd | 5.6 | L.kg-1 | - |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine