Assay Detail
Binding
CHEMBL907269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitory effect of carboxylic acid group on hERG binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.64 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL914 | FEXOFENADINE | 4.0 | 1 | 4.64 |
| CHEMBL583 | GREPAFLOXACIN | 4.0 | 1 | - |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | - |
| CHEMBL1000 | CETIRIZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL914 | FEXOFENADINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL583 | GREPAFLOXACIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL17157 | TERFENADINE | IC50 | = | 56000.0 | nM | - |
| CHEMBL1000 | CETIRIZINE | IC50 | > | 30000.0 | nM | - |