Assay Detail
Binding
CHEMBL3424160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
CNS drug design: balancing physicochemical properties for optimal brain exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.95 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.25 |
| CHEMBL914 | FEXOFENADINE | 4.0 | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL914 | FEXOFENADINE | Ki | = | 23000.0 | nM | 4.64 |