Assay Detail
Binding
CHEMBL3424342
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Inhibition of Escherichia coli DNA gyrase after 1 hr by agarose gel electrophoresis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.82 |
| CHEMBL2313966 | — | — | 1 | 5.22 |
| CHEMBL2313969 | — | — | 1 | 5.20 |
| CHEMBL2313964 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2313966 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL2313969 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL2313964 | — | IC50 | = | 9780.0 | nM | 5.01 |