Assay Detail
Binding
CHEMBL3424482
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Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytochrome P450 11B1, mitochondrial (CHEMBL4970) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.99 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3421769 | — | — | 1 | 6.79 |
| CHEMBL3421770 | — | — | 1 | 6.43 |
| CHEMBL3421780 | — | — | 1 | 6.36 |
| CHEMBL3421779 | — | — | 1 | 6.26 |
| CHEMBL3421768 | — | — | 1 | 6.19 |
| CHEMBL3421785 | — | — | 1 | 6.15 |
| CHEMBL3421766 | — | — | 1 | 5.88 |
| CHEMBL3421765 | — | — | 1 | 5.83 |
| CHEMBL2165320 | — | — | 1 | 5.82 |
| CHEMBL3421767 | — | — | 1 | 5.68 |
| CHEMBL2417553 | — | — | 1 | 5.61 |
| CHEMBL3421786 | — | — | 1 | 5.54 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 5.34 |
| CHEMBL428780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3421769 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL3421770 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3421780 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL3421779 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL3421768 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL3421785 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL3421766 | — | IC50 | = | 1307.0 | nM | 5.88 |
| CHEMBL3421765 | — | IC50 | = | 1493.0 | nM | 5.83 |
| CHEMBL2165320 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3421767 | — | IC50 | = | 2083.0 | nM | 5.68 |
| CHEMBL2417553 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL3421786 | — | IC50 | = | 2849.0 | nM | 5.54 |
| CHEMBL934 | METYRAPONE | IC50 | = | 4607.0 | nM | 5.34 |
| CHEMBL428780 | — | IC50 | > | 10000.0 | nM | - |