Assay Detail
Functional
CHEMBL3424866
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Growth inhibition of human DBTRG cells after 14 to 21 days by soft agar assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DBTRG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.09 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431805 | — | — | 1 | 6.30 |
| CHEMBL3422630 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431805 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3422630 | — | IC50 | = | 1310.0 | nM | 5.88 |