Assay Detail
Functional
CHEMBL3424868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human DLD1 cells after 14 to 21 days by soft agar assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.26 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431805 | — | — | 1 | 6.37 |
| CHEMBL3422630 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431805 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3422630 | — | IC50 | = | 710.0 | nM | 6.15 |