Assay Detail
Binding
CHEMBL3424869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Tankyrases 1 (unknown origin) by autoPARsylationassay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-1 (CHEMBL6164) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.36 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431805 | — | — | 1 | 7.96 |
| CHEMBL3422630 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431805 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3422630 | — | IC50 | = | 18000.0 | nM | 4.75 |