Assay Detail
Binding
CHEMBL3424997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
41
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.83 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 8.80 |
| CHEMBL3422009 | — | — | 1 | 8.70 |
| CHEMBL3422014 | — | — | 1 | 8.60 |
| CHEMBL3422018 | — | — | 1 | 8.50 |
| CHEMBL3422015 | — | — | 1 | 8.50 |
| CHEMBL3422016 | — | — | 1 | 8.20 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 8.10 |
| CHEMBL3422007 | — | — | 1 | 8.00 |
| CHEMBL3422008 | — | — | 1 | 7.90 |
| CHEMBL3422010 | — | — | 1 | 7.90 |
| CHEMBL3422006 | — | — | 1 | 7.60 |
| CHEMBL3422017 | — | — | 1 | 7.60 |
| CHEMBL3421999 | — | — | 1 | 7.20 |
| CHEMBL3421982 | — | — | 2 | 7.12 |
| CHEMBL3422012 | — | — | 1 | 7.10 |
| CHEMBL3422013 | — | — | 1 | 7.10 |
| CHEMBL3422005 | — | — | 1 | 7.00 |
| CHEMBL3422011 | — | — | 1 | 6.50 |
| CHEMBL3422004 | — | — | 1 | 6.40 |
| CHEMBL3421994 | — | — | 1 | 6.30 |
| CHEMBL3422000 | — | — | 1 | 6.30 |
| CHEMBL3421998 | — | — | 1 | 6.10 |
| CHEMBL3421989 | — | — | 1 | 5.90 |
| CHEMBL3422001 | — | — | 1 | 5.80 |
| CHEMBL3421996 | — | — | 1 | 5.80 |
| CHEMBL3421990 | — | — | 1 | 5.70 |
| CHEMBL3421983 | — | — | 2 | 5.35 |
| CHEMBL3421985 | — | — | 1 | 5.30 |
| CHEMBL3421991 | — | — | 1 | 5.30 |
| CHEMBL3422002 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL3422009 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL3422014 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL3422018 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3422015 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3422016 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL10188 | TALNETANT | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL3422007 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3422008 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3422010 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3422017 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3422006 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3421999 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL3421982 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3422013 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3422012 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3421982 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL3422005 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3422011 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL3422004 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL3421994 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL3422000 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL3421998 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL3421989 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL3422001 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL3421996 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL3421990 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL3421983 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3421983 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL3421985 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL3421991 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL3422002 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL3421997 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL3421995 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL3422003 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421984 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421986 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421987 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421988 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421992 | — | Ki | > | 31622.78 | nM | - |
| CHEMBL3421993 | — | Ki | > | 31622.78 | nM | - |